Phentermine 37.5 mg was first introduced to the United States as a new kind of weight loss drug. Throughout the decades, Phentermine has continued to be one of the most popular weight-loss drugs available today.
Although coming under public scrutiny in the 1970’s, this drug has persevered and still accounts for over half of all the weight loss prescriptions written in the United States each year.
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History of Phentermine
Phentermine 37.5 mg received FDA approval in 1959. It was approved for weight loss and was classified as an appetite suppressant. It was to be used only for a short period of time, generally from eight to 12 weeks at a time. Physicians in the United States were able to prescribe this medication to their patients in the same year.
As the years passed, Phentermine became available in a hydrochloride form. This new formulation first appeared in the 1970’s, and is the form that physicians use today. In the 1990’s, Phentermine coupled up with another popular prescription weight-loss drug called fenfluramin.
This popular combination drug was known as Phen-fen. Phen-fen was largely prescribed when it first became available, until consumers who had used the drug were beginning to experience heart-valve disorders and potentially fatal cases of pulmonary hypertension. The cocktail was removed from the market in the late 1990’s as a result, and fenfluramine and its counterpart, dexfenfluramine were both banned by the FDA. Despite the hoopla around the popular Phen-fen combination, Phentermine remains available by prescription today.
How does Phentermine work?
Phentermine belongs to a class of medications otherwise known as amphetamines. While there are many illicit drugs that belong to the same classification of medications, Phentermine varies from these drugs greatly. Phentermine HCL, the drug that is prescribed today, controls appetite by working on the central nervous system of the user, namely by stimulating the hypothalamus to produce neurotransmitters. These neurotransmitters affect the way the brain receives signals of hunger as well as signals of being full.
Phentermine HCL reaches peak blood concentration levels in approximately three to four and a half hours after oral administration. There is not an extended form of the drug form known as Adipex, and users tend to achieve highest blood concentrations when taking this drug. Other formulations offer a controlled-release form of the drug.
What is Phentermine used for?
Phentermine 37.5 mg is used for controlled, rapid weight loss in individuals with a body mass index, or BMI, over 30 kg/m². It is also used for those with a BMI over 27 kg/m² who have another controlled illness, such as diabetes or hyperlipidemia. This drug is designed to be used in combination with a reduced-calorie diet and exercise regimen.
Phentermine is designed to be used for short periods of time, normally for a period of eight to 12 weeks. If the drug loses its efficacy after a few weeks, which is a common problem, it is to be discontinued, rather than attempting to use the drug at an increased dosage.
Other names for Phentermine
Phentermine is actually the generic name for this medication. The drug is available under many different brand or trade names, depending on the manufacturer and whether or not the drug is the original form or the 37.5 mg HCL formulation. Adipex-P is the most widely prescribed name brand form of this drug, and it is available in 37.5 mg or 50 mg capsules or tablets.
Another trade name for Phentermine is Ionamin. This formulation comes in 15 mg and 30 mg capsules. Duromine, another trade name, is available in 15 mg, 30 mg and 40 mg capsules. Generally it’s most effective at the 30 mg dose. Fastin, one prescription form of Phentermine, is no longer available in the United States. It came in 30 mg tablets. One last popular trade name is Oby-Trim. There are many other trade names for Phentermine, depending on the manufacturing pharmaceutical company and the country the medication is coming from.
